摘要
目的 :探讨难治性急性髓细胞性白血病的治疗方法。方法 :对临床上不能耐受标准化疗的难治性急性髓细胞性白血病 (AML) 7例 ,应用α 干扰素 (α IFN)联合小剂量高三尖杉酯碱和阿糖胞苷 (LD HA)方案治疗。结果 :7例难治性AML病人达到CR的有 4例 (5 7.14 % ) ,达到PR的有 1例 (14 .2 9% ) ,NR有 2例 ,总有效率为 71.4 3%(5 / 7)。结论 :本方案可明显提高难治性AML的缓解率 ,对于过渡到标准剂量强化治疗创造机会具有积极意义 。
Objective: To investigate the clinical therapeutic efficacy of small dose HA combined with Interferon alphain in refractory acute myelocytic leukemia(AML).Methods:Seven patients with refractory AML who could not undergo standard chemical treatment were treated with small dose homoharringtonine and cytarabine(LD HA) combined with interferon alpha.Results:The complete remission rates(CR) were 57.14%(4/7) and partial remission rate(PR) was 14.29%(1/7). Only 2 patients turned out with non remission(NR).The total effective rate was 71.43%(5/7).Conclusion:This therapy can obviously upgrade the remission rate of refractory AML, which provides a good opportunity for further standard chemical treament. LD HA in combined with interferon alpha is a better choice for refractory AML.
出处
《实用临床医学（江西）》
CAS
2003年第3期53-56,共4页
Practical Clinical Medicine
关键词
白血病
髓细胞性
准治性
Α干扰素
HA方案
leukemia
myelocytic
refractory
interferon alpha
homoharringtonine
