蝮蛇抗栓酶复合剂预防腹腔粘连的实验及临床研究

Experiment and clinic research on prevention of abdominal cavity adhesion by Pallas Pit Viper anti-blocking enzyme compound agent

目的 探讨蝮蛇抗栓酶对术后腹腔粘连及粘连性肠梗阻的预防作用。方法 采用两种腹腔粘连的动物模型 ,分别将 6 0只大白鼠和 4 0只大白兔各均分为实验组和对照组 ,观察腹腔粘连情况 ;将 112例粘连性肠梗阻手术病人随机分为实验组和对照组 ,随访 18个月 ,观察粘连性肠梗阻复发率。结果 在动物实验和临床应用中 ,实验组的粘连百分比均显著低于对照组 (P <0 0 1)。结论 蝮蛇抗栓酶复合剂可有效地预防腹腔粘连及粘连性肠梗阻的发生 ,且不良反应少。

Objective To study the preventing effect of Pallas Pit Viper anti-blocking enzyme compound agent on abdominal cavity adhesion as well as adhesive ileus after operation.Methods Two kinds of animal model of abdominal cavity adhesion were adopted to our test.Sixty white rats and 40 white rabbits were divided equally into experimental group and control group respectively,of which the situation of abdominal cavity adhesion were observed.In addition,112 patients of adhesive ileus after operation were divided into experimental group and control group in random,of which the recurrence rate of adhesive ileus were observed during the follow-up survey within 18 months hereafter.Results In both animal and clinical applications,the adhesion percents of experimental group were obviously lower than those in control group(P<0.01).Conclusion Pallas Pit Viper anti-blocking enzyme compound agent do have an obvious effect on preventing abdominal cavity adhesion as well as adhesive ileus with litter side reaction.