心血瘀阻证遗传倾向的调查分析

A Survey on the Hereditary Tendency of the Pattern of Heart-Blood Stasis-Obstruction

目的分析冠心病、高血压病、糖尿病性心脏病心血瘀阻证的遗传倾向。方法运用家系分析法对 5 4例心血瘀阻证患者和 5 4例健康人的家族进行了遗传分析 ,检测一级亲属发病率、遗传率 ,及 3种父母婚配类型子女发病的相对危险度 (RR)及其 95 %可信区间 ( 95 %CI)。结果心血瘀阻证患者的一级亲属发病率为 7.62 %,健康对照组为 0 .95 %,两组比较有显著差异 (P <0 .0 0 1 ) ;心血瘀阻证的遗传率为 ( 67.4±6.89) %;以“双亲均正常”组为对照 ,“亲代一方患病”组的RR值为 3 .46,“亲代双方患病”组的RR值为 5 .84,提示子女患心血瘀阻证与亲代双方患病有因果关系。结论心血瘀阻证可能是一种具有遗传倾向的“多基因证”。

?Objective To survey the hereditary tendency of the pattern of Heart blood stasis obstruction (HBSO)in the population with coronary heart disease,hypertensive cardiopathy and diabetic cardiopathy. Methods Hereditary analysis was carried out among 54 families with a proband of HBSO pattern and 54 families with one person selected at first as healthy people as control with family line investigation method.During this process,tested were the I degree relative morbidity,heritability and RRs and their 95% CI of offspring morbidity from 3 types of parental marriage.Results The morbidity of HBSO pattern was 7.62% in the population of I degree relatives and 0.95% in that of healthy controls,with significant difference between them (P<0.001).Then,the heritability of this pattern was (67.4±6.9)% for them.When the persons in the group with parents being all healthy were taken as controls,the value of RR was 3.46 in the group with one of the parents being ill and 5.84 in the one with both of the parents being ill. This suggested that there was a causal relationship between the morbidity of HBSO pattern in offsprings and the ill occurrance of this condition in parental generation.Conclusion HBSO pattern may be 'one involved in multiple genes'with hereditary tendency. 〔