急性脑梗塞患者粘附分子CD_(18)、CD_(54)表达的研究

The research of expression of cell adhesion molecules CD_(18), CD_(54) in patients with acute cerebral infarction(ACI)

[目的]探讨粘附分子CD18、CD54粘附功能及其表达变化与急性脑梗塞(ACI)关系.[方法]用流式细胞术检测88例ACI患者白细胞粘附分子CD18、CD54含量与脑梗塞发生时程、部位、面积及治疗前后表达。并与30例正常人作对照.[结果]ACI患者CD18、CD54表达明显增高,与正常对照组比较差异显著(P<0.05),与梗塞面积、部位关系不大;ACI患者CD18、CD54表达在7d内均可有较高水平的表达,治疗10d后表达降低,治疗前后比较CD18、CD54差异有意义(P<0.05).[结论]CD18、CD54参与脑梗塞发生发展病理过程.可做为诊断脑梗塞、评估预后的一项辅助指标.

[Objective] To explore the relation between adhesion function and change of expression of cell adhesion molecules CD18, CD54 with acute cerebral infarction (ACI). [Methods] With flow cell method (FCM), to detect occurrence time, place, area and expression of leukocyte adhesion molecules CD18, CD54 in 88 acute cerebral infarction patients with 30 controls, before and after treatment. [Results] The expression of CDI8, CD54 with acute cerebral infarction (ACI) increases obviously. It is significantly different from that of the controls (P<0.05) and not correlated with occurrence place and area. The change of CD18, CD54 before and after treatment is significant (P<0.05). The levels of the expression increase in seven days and decrease after ten days. [Conclusion] CD18, CD54 might take part in occurrence of ACI pathology process and can be additional diagnosis inder for ACI.