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D2型多巴胺受体配基的研究进展 被引量：2

Recent advances in the structure activity relationship of dopamine D2-like receptor ligands
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摘要 阐述了近几年D2型受体配基的研究状况 ,探讨了部分具有应用前景的化合物的构效关系。特别指出混合受体拮抗剂 (如d2 /d4、d2 / 5HT1A)和部分激动剂可能成为新的非经典抗精神失常药物 ,而兼有抗氧化作用的多巴胺受体激动剂则成为抗帕金森病药物研究的主要方向。 A study of dopamine D2-like receptor ligand in recent five years have been introduced,and emphasis was placed on the structure-activity relationship of the valuable compounds.The d_2/d_4 or d_2/5HT_ 1A mixed antagonists may be the most hopeful novel nonclassical antipsychotic drug.New dopamine agonists which show antioxidant activity are the potential drugs for the treatment of the Parkinson′s disease.
作者 成冲云 姜凤超
机构地区 华中科技大学同济医学院药学院
出处 《中国药物化学杂志》 CAS CSCD 2003年第3期179-186,共8页 Chinese Journal of Medicinal Chemistry
关键词 药物化学 构效关系 综述 多巴胺受体 多巴胺受体配基 抗精神失常 帕金森病 medicinal chemistry structure-activity relationship review dopamine receptor dopamine receptor ligand schizophrenia Parkinson′s disease
分类号 R914 [医药卫生—药物化学]
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参考文献31

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同被引文献29

  • 1罗庆华,蒙华庆.齐拉西酮——新型非典型抗精神病药物应用研究[J].重庆医学,2007,36(6):496-498. 被引量：35
  • 2张刚,陈玉彬.新型抗精神病药物的研究进展[J].中国药物化学杂志,2007,17(3):188-192. 被引量：9
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  • 4TALAGA P , MATAGNE A, KLITGAARD H. Pharmacological evaluation of a diary-lmethylene-piperidine derivative: a new potent atypical antipsychotic [J ].Bio Med Chem Lett,2001,11 (10) : 1313 -1316.
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  • 6TORT A B L, SOUZA D O , LARA D R. Theoretical insighls into the mechanism of action of atypical antipsychotics [ J ]. Prog Neuro-Psyc Biol Psyc, 2006,30 (5) : 541 -548.
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  • 10MARIO A ,ALBERTO C, MASAGUER C F. Synthesis and binding affinity of novel 3-aminoethyl-1-tetralones, potential atypical antipsychotics [ J ]. Bio Med Chem Lett, 2005,15(15) : 3063 -3066.

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中国药物化学杂志
2003年 第3期

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