肉毒毒素A治疗痉挛型脑瘫探讨

Observation of botulinum toxin A applying in treatment of spastic cerebral palsy

目的探讨肉毒毒素 A(botulinum toxin A,BTX- A)在脑瘫康复治疗中的应用价值。方法将 4 7例痉挛型脑瘫儿童随机分为治疗组 (32例 )和对照组 (15例 ) ,两组均接受正规康复训练 ,治疗组辅以痉挛肌注射 BTX- A,观察两组患儿的内收肌角与日常生活活动能力 (activities of daily living,ADL)变化。结果治疗 3个月和 6个月后 ,治疗组患儿的内收肌角、ADL 改善情况明显优于对照组 (P<0 .0 1)。结论康复训练仍是有效的脑瘫治疗手段 ,BTX- A局部注射作为一种重要的辅助方法 ,可为康复训练提供良好时机 ,两者结合可明显缩短疗程、提高疗效 ,在脑瘫康复治疗中具有应用价值。

ObjectiveTo observe the effect of botulinum toxin A (BTX-A) in rehabilitation training on cerebral palsy (CP).Methods47 CP children were randomly divided into the treatment group (32 cases) and control group (15 cases). Both groups were received rehabilitation training. But cases of the treatment group were injected with BTX-A in part of spastic muscles. Angles of inner contraction muscle (AICM) and activities of daily living (ADL) of two groups were observed for 6 months.ResultsImprovements of AICM and ADL in the treatment group were significantly better than that in the control group ( P<0.01).Conclusions The rehabilitation training still is a kind of efficient treatment method. BTX-A injecting in part of spastic muscles is a kind of efficient assistant method and furnishes a better chance for rehabilitation training. Rehabilitation training combining with BTX-A injection can clearly curtail period of treatment, raise curative effect. BTX-A injection has significant applicable value in treatment on cerebral palsy.