摘要
目的 探讨转化生长因子 β1 在阿尔茨海默病发生中的作用。 方法 用双抗体夹心ELISA法检测32例阿尔茨海默病患者和 2 0例正常人血清TGF β1 含量 ,两者加以比较。 结果 阿尔茨海默病组TGF β1 含量明显低于正常组 ,两组间存在显著性差异 (t =2 87,0 0 0 5 <P <0 0 1) (双侧 )。 结论 TGF β1 可能通过影响细胞的增殖分化、神经元转移及轴突形成、抗原表达及细胞毒等作用 。
Objective To study the effects of transforming growth factor β 1(TGF β 1) in Alzheimer’s Disease(AD) Methods There were 32 AD patients whose serum concentration of TGF β 1 was tested and compared with that of 20 normal persons Results The serum concentration of TGF β 1 in the AD patients(20 59ng/ml±10 49ng/ml) was lower than the normal persons’(30 08ng/ml±13 17ng/ml)(t=2 87,0 005<P<0 01) There was significant differences between the two groups Conclusion TGF β 1 is possibly concerned with the occurrence and progress of Alzheimer’s Disease
出处
《实用心脑肺血管病杂志》
2003年第3期139-140,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
