阿伦膦酸钠对不同年龄骨质疏松症的疗效比较

THE EFFECT OF ALENDRONATE ON OSTEOPOROSIS IN DIFFERENT AGED GROUPS

目的观察阿伦膦酸钠对原发性骨质疏松不同年龄绝经后妇女骨密度的治疗反应和安全性。方法绝经后妇女264名,其中51～69岁组l43例(I组),70～85岁组12l例(II组)。所有病人均给予阿伦膦酸钠,于服药后3、6、9、12月随访,进行有效性、安全性和服药顺应性的监测。结果治疗6月后BMD改变值(mg/cm2):I组L2-4+38±24,HiP+17±26,Ward's+10±28,大转子-2±36。II组L2-4+30±29Hip+21±42,Ward's+6±36,大转子+2±32。治疗l2月后BMD改变值(mg/cm2):I组L2-4+44±32,Hip+26±39,Ward's+22±42,大转子+8±40。II组L2-4+40±41,HiP+29±34,Ward's23±46,大转子+6±36。两组在治疗期间I组右前臂远端骨折l例,II组未发生新骨折。血、尿、大便常规、肝肾功能无异常变化。结论服用阿伦膦酸钠治疗后,高龄老人和低龄老人腰椎和股骨颈部BMD均有升高,高龄组股骨颈部BMD的增幅略高于年龄低的一组。高龄老人对阿伦膦酸钠的反应与低龄老人相似,无特殊年龄安全性问题。

Objective To observe the effect and safety of alendronate on postmenopausal osteoporosis patients in different age groups. Methods 264 Postmenopausal female were enrolled in the study,they were divided into two groups,143 women(age 51～69years)in group I,121 women(age70～85years)in group II. All of the patients were administered with alendronate. The effect, reliability and compliance of the drng were monitored 3,6,9,12 months after taking it. Results The study also suggested a positive effect of alendronate on BMD of these patients. The value of BMD showed L2-4 38±24,Hip +17±26,Ward's +10±28,Troch -2±36(mg/cm2)in group I and L2-4 +30±29,Hip+21±42,Ward's +6±36,Troch +2±32(mg/cm2)in group II after 6 months;L2-4 +44±32 HiP +26±39,Ward's+22±42,Troch +8±40(mg/cm2)in group I, and L2-4 +40±41,Hip +29±34,ward's +23±46,Troch +6±36(mg/cm2)in group II after 12 months. During the course,one patient suffered from fracture in group I,and no fracture In group II. No abnormality of blood,urine and stool routine tests including liver and renal functions were found in both groups. Conclusions BMD in femur neck and lumbar spine sites was increased in two groups after alendronate treatment.Therewas no significant deference of BMD in them. The increase of femur neck BMD in group II was a little higher than that in group I. Group I was similar to group II in the effect,reactivity and compliance taking alendronate. There was no special age difference in safety of the treatment.