原发性高血压患者微量蛋白尿与早期肾损害

The relationship between the microproteinuria and early kidney damage in essential hypertension patients,

目的:探讨尿液微量蛋白与高血压病(EH)早期肾功能损害的关系。方法:用速率免疫散射比浊法测定了105例EH患者和32例正常对照者的尿液微量白蛋白(mAL)、白蛋白(ALB)、α_1微球蛋白(α_1-MG)、β_2微球蛋白(β_2-MG)。结果:EH患者早期即有α_1-MG水平的升高(P<0.05)。结论:尿液α_1-MG的测定有利于EH患者肾功能损害的早期诊断、治疗。

Objective: To study the relationship between urinary microprotein and early kidney damage in essential hypertension patients. Methods; A total of 105 patients and 32 healthy subjects were measured for urinary microalbumin (mAL), albumin (ALB), α1-microglobulin (ai-MG)., β2-MG by rate immuno-nephelometry. Results: The urinary ai-MG concentration significantly elevated (P<0. 05) in EH patients compared with that of healthy subjects. Conclusion: The urinary α1-MG is an initial parameter to predict early kidney damage in EH.