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伊贝沙坦治疗左心功能不全的疗效评价 被引量:3

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摘要 目的:评价伊贝沙坦治疗左心功能不全的疗效及安全性。方法:61例左心功能不全患者按随机单盲法被分为观察组和对照组两组。观察组31例给予伊贝沙坦治疗,对照组30例以地高辛口服,连用8周,进行对比观察,用多普勒超声心动图评定心功能变化。结果:观察组用药后左心收缩功能指标:心输出量、左室射血分数显著增大(P<0.01),舒张功能指标(E、A、E/A、DC)亦明显改善(P<0.01)。对照组仅收缩功能指标改善(P<0.05),舒张功能指标无变化(P>0.05)。表明伊贝沙坦对左心收缩功能不全、舒张功能不全均有治疗作用,而地高辛仅改善收缩功能,对舒张功能不全无有益影响。伊贝沙坦治疗期间未见严重不良反应。结论:伊贝沙坦是治疗左心功能不全的一种有效而安全的药物。
出处 《心血管康复医学杂志》 CAS 2003年第3期238-240,共3页 Chinese Journal of Cardiovascular Rehabilitation Medicine
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  • 1[2]Kitzman D W.Heart failure with normal systolic function.Clin Geriatr Med,2000,16(3):489-512.
  • 2[3]Pinamnonti B,di Lenarda A,Sinagra G.Heart failure due to diastolic dysfunction:The treatment principles.Ital Heart J,2000,1(4 Suppl):469-480.
  • 3[4]Zile M R,Nappi J.Diastolic heart failure.Curr Treat Options Cardiovasc Med,2000,2(5):439-450.
  • 4[5]Mandinov L,Eberli F R,Seiler C,et al.Diastolic heart failure.Cardiovasc Res,2000,45:813-825.
  • 5[6]Brown L,Duce B,Mitic G,et al.Reversal of cardiac fibrosis in deoxycorticosterone acetate-salt hypertensive rats by inhibition of the renin-angiotensin system.J Am Soc Nephrol,1999,11(5):S143-148.
  • 6[7]Brilla C G,Funck R C,Rupp H.Lisinopril-mediated regression of myocardial fibrosis in patients with hypertensive heart disease.Circulation,2000,102(12):1342-1345.
  • 7[8]Warner J G Jr,Metzger D C,Kitzman D W,et al.Losartan improves exercise tolerance in patients with diastolic dysfunction and a hypertensive response to exercise.J Am Coll Cardiol,1999,33(6):1567-1572.
  • 8[9]Sun Y,Weber K T.Infarct scar:A dynamic tissue.Cardiovasc Res,2000,46(2):250-256.
  • 9[10]Verdecchia P,Schillaci G,Reboldi G P,et al.Long-term effects of losartan and enalapril,allone or with a diuretic on ambulatory blood pressure and cardiac performance in hypertension:A case-control study.Blood Press Monit,2000,5(3):187-193.
  • 10[11]Liu Y H,Yang X P,Mehta D,et al.Role of kinins in chronic heart failure and in the therapeutic effect of ACE inhibitors in kininogen-deficient rats.Am J Physiol Heart Circ Physiol,2000,278(2):H507-514.

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  • 1沈哲.氯沙坦治疗特发性扩张型心肌病疗效观察[J].实用临床医药杂志,2004,8(5):84-84. 被引量:2
  • 2姜红,戴闺柱.心力衰竭患者心功能的评定──6分钟步行试验与运动峰耗氧量对比研究[J].临床心血管病杂志,1995,11(5):270-272. 被引量:12
  • 3心肌病诊断与治疗建议[J].中华心血管病杂志,2007,35(1):5-16. 被引量:547
  • 4艾虎,刘波,孙福成.老年扩张型心肌病的临床特点分析[J].中国临床保健杂志,2007,10(2):137-140. 被引量:8
  • 5Solomon SD, Lynn RJ, Graves S, et al. Recovery of ventricular function after myocardial infarction in the reperfusion era: the healing and early after load reducing therapy study [J]. Ann Intern Med, 2001, 134,451--458.
  • 6Rostagno C, Galanti G, Komano I, et al. Prognosis value of 6 --minute walk corridor test in women with mild to moderate heart failure [J]. ItalHeartJ, 2002, 3 (2):109--113.
  • 7Guimaraes GV, Bellotti G, Bacal F. Can the cardiopulmonary 6 --minute walk test reproduce the usual activities of patients with heart failure [J]. ArqBrasCardiol, 2002, 78 (6):553--560.
  • 8Yamada T, Shimonagata T, Fukunami M, et al. Comparison of the prognostic value of cardiac iodine-123 metaiodobenzylguanidine imaging and heart rate variability in patients with chronic heart failure : a prospective study [ J ]. J Am Coll Cardiol, 2003,41 ( 2 ) : 231-238.
  • 9Grimm W, Herzum I, Muller HH ,et al. Value of heart rate variability to predict ventricular arrhythmias in recipients of prophylactic defibrillators with idiopathic dilated cardiomyopathy [ J ]. Pacing Clin Electrophysiol,2003,26( 1pt 2) :411- 415.
  • 10Solomon SD, Lynn R J, Graves S, et al. Recovery of ventricular function after myocardial infarction in the reperfusion era: the healing and early afterload reducing therapy study [ J ]. Ann Intern Med,2001,134(6) :451- 458.

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