疱疹口服液药效学实验研究

Study on Drug Effect Experimentation of Peroral Liquor for Herpes

目的 :探讨疱疹口服液的药效机制。方法 :以龙胆泻肝汤颗粒为对照组 ,分别观察疱疹口服液对由角叉菜胶所致大鼠足爪肿胀和对二甲苯引起小鼠耳廓肿胀的抗炎作用 ,由热板法引起小鼠疼痛的镇痛作用 ,由伤寒甲乙三联菌苗引起家兔发热的解热作用 ,以及对 HSV-1、HSV-2、VZV和 HSV-1吴株的抗毒作用。结果 :疱疹口服液对非特异性急性炎症有较好的抗炎、镇痛作用 ,有明显的解热作用 ,对 HSV-1、HSV-2、VZV和 HSV-1吴株有明显的抗毒作用。其抗炎、解热和抗毒作用与龙胆泻肝汤相似 ,而其镇痛作用优于龙胆泻肝汤。结论 :疱疹口服液具有明显的抗炎、镇痛、解热、抗毒作用 。

Objective:To explore the pharmacologyical mechanism of Paozhen decoction.Methods:Experinental animals were randomly diveded into 5 groups treated with Paozhen decoction compared with a conteol group treated wirh Longdanxiegan as positive control and a normal saline group as negative control.The different effects of anti inflammatory anelgesia,anti pyretia,anti toxicity,were observed.Results:Compared with the control group Paozen decoction showed renarkable effects of anelgesia.The difference of anti inlammatory anti pyretic anti toxicity.butween the Psozen decoction and Longganxiedan was insignificant.Conclusion:Paozhen decoction showed obvious effects of anti inlammatory,analgesia,anti pyretic,anti toxicity.Maybe it is a high effective drug for herpes zoster treatment.It has a good prospect of development and application.