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CD44在腹腔肿瘤腹膜转移中的意义 被引量:3

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摘要 CD44作为多功能粘附分子,与肿瘤转移的粘附过程密切相关。腹腔肿瘤细胞CD44的表达,促进了肿瘤细胞与腹膜组织的粘附,从而在腹膜转移形成的初始阶段发挥重要作用。腹膜转移过程中常出现与肿瘤转移相关表位结构的CD44分子的表达,主要是CD44变异体的表达,胃癌和卵巢癌尤其明显。对这些变异体的深入研究,有助于阐明腹腔肿瘤腹膜转移的机理。通过抑制CD44的表达或阻断其作用,对腹腔肿瘤的腹膜转移有一定的抑制作用。
出处 《国外医学(消化系疾病分册)》 2003年第3期158-161,共4页
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同被引文献19

  • 1罗华星,余佩武,王自强,钱锋,青廉,周立新.腹腔镜辅助下胃癌根治术对机体免疫功能的影响[J].第三军医大学学报,2005,27(9):910-912. 被引量:21
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