西安市男性吸烟、饮酒与食管癌关系的Meta分析

Meta analysis of the relationship between tobacco consumption, drinking and esophageal cancer among males in Xi'an

目的 探讨西安市男性吸烟、饮酒与食管癌的病因关系。方法 应用Meta分析对吸烟、饮酒与食管癌病例对照研究的文献进行综合评价。结果 纳入本次Meta分析的 5篇研究吸烟的文献中 ,病例组 5 30例 ,对照组 4 0 0 5例 ,异质性检验结果P >0 .0 5 ,支持固定效应模式 ,计算的OR为 2 .88(2 .32～ 3.5 8)。研究饮酒的 4篇文献中 ,病例组 4 6 5例 ,对照组 385例 ,异质性检验P <0 .0 5 ,按随机效应模式计算的OR为 1.81(1.0 8～ 3.0 5 )。结论 吸烟、饮酒与食管癌呈中等联系强度 ,是西安市男性食管癌的危险因素。

Objective To investigate the relationship between tobacco consumption, drinking andesophageal cancer among males in Xi' an. Methods We used meta analysis to evaluate the previous case-controlstudies on relationship between smoking, drinking and esophageal cancer. Results In this meta analysis, theheterogeneity test results of 5 literatures about the relation of smoking and cancer which recruited 530 cases and4005 controls supported the fixed effect model ( P > 0.05), whose pooled OR was 2.88 (95 % CI: 2.32 - 3.58)while the heterogeneity test results of 4 literature about the relation of drinking and cancer which recruited 465cases and 385 controls did not support the fixed effect model (P<0.05), whose pooled OR was 1.81 (95%CI:1.08 - 3.05) following the random effect model. Conclusion The correlation is of intermediate degree betweensmoking, drinking and esophageal cancer separately, which is the risk factor of esophageal cancer among males inXi'an.