紫草活血汤治疗银屑病的疗效及对血液流变学的影响

Clinical and hemorrheological observation of psoriasis treated with Zicaohuoxue Decoction

目的 评价紫草活血汤治疗寻常型银屑病的临床疗效及对血液流变学的影响。方法 采用紫草活血汤治疗92例寻常型银屑病 ,观察治疗前后皮损面积、红斑丘疹、鳞屑、瘙痒、PASI积分及血液流变学的变化。结果 临床治疗有效率 97.5 %。银屑病各主证积分、PASI积分治疗后较治疗前显著下降 (P <0 .0 1)。高切血液黏度、低切血液黏度、血浆黏度、红细胞压积比、血沉、红细胞聚集指数等血液流变学指标在治疗后与治疗前比较有显著性下降(P <0 .0 5 )。结论 紫草活血汤能降低寻常型银屑病患者的血液黏度 。

Objective To investigate the effect of psoriasis vulgaris treated with Zicaohuoxue Decoction and the influence on hemorrheology. Methods Ninety two patients in the experimental group treated with Zicaohuoxue Decoction were observed before and after treatment. Results There were significantly differences in skin lesion area, erythema, papule, scale, pruritus, global psoriasis area and severity index before and after teatment ( P < 0.01 ). As for hemorrheological markers, there were significant differences in blood viscosity, plasma viscosity,erythrocyte sedimentation rate,haematocrit, erythrocyte aggregation index before and after treatment ( P < 0.05 ). Conclusion The blood viscosity is decresed after patients with psoriasis vulgaris are treated with Zicaohuoxue Decoction .The clinical effect of psoriasis vulgaris treated with Zicaohuoxue Decoction is satisfactory.