具有免疫刺激活性的非甲基化寡核苷酸链的研究进展

Progress in Unmethylated Immunostimulatory Oligodeoxynucletides

富含非甲基化碱基CG的寡核苷酸链 (CpG oligodeoxynucleotides,CpG ODN) ,具有免疫刺激活性 .其骨架及侧翼核苷酸序列决定CpG ODN免疫效应的强度及特异性 .最近研究发现 ,通过对CpG ODN中核苷酸上的基团进行化学修饰 ,或改变侧翼核苷酸序列均能影响CpG ODN的免疫活性、种属及细胞特异性 .这对CpG

Unmethylated CG-rich oligodeoxynucletides are exhibiting several immunological effects. The backbone and the flanking sequences of CpG-ODN decide the potence and specificity of its immunostimulatory effects. Chemical modifications have been systematically in corporated into CpG-ODN and the resulting modified compounds have been studied for immunostimulatory activity, the researches show that they have strong effect on species and cells' speciality, which offer the instruction for the design of CpG-ODN.