^(89)Sr治疗肺癌转移性骨痛的疗效评价

The evaluation of palliative effect of ^(89)Srcl_2 on metastatic bone - pain of pulmonary carcinoma

目的 评价^(89)Srcl_2对肺癌转移性骨痛的临床疗效。方法 观察21例肺癌多发性骨转移伴疼痛患者静脉注射^(89)Srcl_2治疗后的镇痛作用及不良反应。结果 治疗后骨痛减轻或消失18例,总有效率达到85.7％;治疗后骨显像发现转移灶消失或基本消失62处;治疗后有3例病人出现轻度的白细胞、血小板减少,对心、肝、肾几乎没有影响。结论 ^(89)Srcl_2对缓解肺癌骨转移瘤疼痛有较好的疗效,并有一定的治疗作用,副作用小,可重复用药。

Objective To evaluate the palliative effect of 89Sr metastron on metastatic bone-pain of pulmonary carcinoma. Methods Observing the palliative effect and side effect of 21 patients with metastatic bone-pain of pulmonary carcinoma after intravenous 89Sr metastron. Results The bone-pain vanished or releases in 18 patients after therapy. The completely effective rate was 85.7%. Bone scan showed 62 metastatic cancer focals vanished partly or Side effects: The counts of leucocyte and blood platelet were decreased mildly in 3 patients. The damage of heart, liver and kidney was not observed after therapy. Conclusions The 89Sr metastron has obvious effect on beating patients with metastatic bone-pain of pulmonary carcinoma, and the side-effect is mild. And it can be used repeatedly. The results of this study indicate that 89Sr metastron is an useful radionuclide for treating metastatic bone-pain of pulmonary carcinoma.