格列吡嗪控释片治疗对2型糖尿病患者血浆脂过氧化物及肿瘤坏死因子-α水平的作用

Effects of glipizide-GITS treatment on plasma lipid peroxides and tumor necrosis factor-alpha in type 2 diabetes mellitus patients

目的 研究格列吡嗪控释片治疗对 2型糖尿病患者血浆脂过氧化物 ,肿瘤坏死因子 (TNF) α的作用。方法 8例正常健康对照者和 8例用D860治疗控制不佳的 2型糖尿病患者 ,改用相当降糖剂量的格列吡嗪控释片 ,于治疗前和治疗后 3个月取 2型糖尿病患者静脉血测血浆脂过氧化物及TNF α ,并与对照组比较。结果 2型糖尿病患者血浆脂过氧化物水平和TNF α水平高于对照组 ,格列吡嗪控释片能使之降低至对照组相似的水平。结论 格列吡嗪控释片能降低 2型糖尿病患者血浆脂过氧化物及TNF α ,因而有助于防治

Objective To evaluate the effect of glipizide GITS on plasma levels of lipid peroxide and tumor necrosis factor alpha in type 2 diabetes mellitus. Methods Poorly controlled tolbutamide treated diabetic patients ( n =8) and healthy control subjects ( n =8) were recruited. At the beginning of the study, tolbutamide was replaced by an equivalent hypoglycemic glipizide GITS. Serum was isolated from blood obtained from the control and diabetic subjects before and after 3 months of treatment with glipizide GITS. Results Plasma lipid peroxide and tumor necrosis factor alpha levels were enhanced in type 2 diabetes mellitus patients, and glipizide GITS administration totally reversed these abnormalities. Conclusion Glipizide GITS administration to type 2 diabetes mellitus patients could reduce lipid peroxide level and production of tumor necrosis factor alpha. resulting with beneficial effect for the prevention of atherosclerosis.