血小板衍生生长因子在肺鳞癌及肺腺癌中的表达及意义

THE EXPRESSION OF PLATELET DERIVED GROWTH FACTOR IN LUNG SQUMOUS CELL CARCINOMA AND ADENOCARCINOMA

目的 探讨血小板衍生生长因子 (PDGF)在肺鳞癌和肺腺癌中的表达及意义。方法 应用免疫组织化学技术观察了PDGF -A链和PDGF -B链在 42例肺鳞癌和 1 5例肺腺癌中的表达 ,并测定了它们在肺非特异性炎症组织中的表达。结果 PDGF -A链和PDGF -B链的表达主要定位于肿瘤细胞胞浆、血管内皮细胞及平滑肌细胞 ,炎症组织的肺泡上皮细胞及血管平滑肌细胞少量表达。PDGF -A链和PDGF -B链在肺鳞癌及肺腺癌中均有显著表达 ;PDGF的过度表达与肿瘤细胞的分化程度无关。结论 PDGF -A链和PDGF -B链的过度表达与肺鳞癌和肺腺癌有关 ;PDGF -A链和PDGF -B链的生物学特征可能有所不同 ,PDGF

Objective\ To study the expression of platelet derived growth factor (PDGF) in lung squmous cell carcinoma and adenocarcinoma. Methods\ The expressions of PDGF-A chain and PDGF-B chain were analyzed in 42 lung squmous cell carcinomas and in 15 lung adenocarcinomas, by histochemical study , compared with that in non specific inflammation of lung tissues.Result\ PDGF -A chain and PDGF-B chain were localized in cytoplasm of tumor cells and mesenchymal and endothelial cells of the two types of lung cancer. Slight expression could be found in aleveolar epithelial cells and vascular endothelial cells in control lung tissues. There were significant overexpression of PDGF-A chain and PDGF-B chain in the lung cancer .There were no correlation between PDGF overexpression and the degree of cell differentiation.Conclusions\ The overexpression of PDGF-A chain and PDGF-B chain could play a potential role in lung squmous cell carcinoma and adenocarcinoma. The biological behaviour of PDGF-A chain and PDGF-B chain might be different, and PDGF-B chain could be more related to neovascularization than PDGF-A chain.