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p73基因失活在儿童急性淋巴细胞白血病发病和预后中的意义 被引量：2

The Significance of p73 Gene Inactivation in the Development and Prognosis of Childhood Acute Lymphoblastic Leukemia
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摘要 目的　探讨p73基因mRNA失表达与儿童急性淋巴细胞白血病 (ALL)的发病和预后的关系。方法　采用反转录聚合酶链反应 (RT -PCR )方法检测了 34例ALL患儿骨髓单个核细胞内 p73mRNA的表达情况 ,并分析了 p73mRNA失表达与化疗的反应及复发的关系。结果　儿童ALL患者中 p73mRNA失表达率达 2 6.5 % ( 9/34 ) ,且与诱导缓解治疗的反应和复发显著相关 (P <0 .0 5 )。结论　p73mRNA失表达在小儿ALL的发病过程中起重要作用 ,p73mRNA检测对评估儿童ALL预后 。 Objective To investigate the relationship between the p73 gene inactivation and the development,prognosis of acute lymphoblastic leukemia in children.Methods The p73 transcripts level of mononuclear cells of bone marrow in 34 children with ALL was detected by reverse transcriptase polymerase chain reaction(RT-PCR) technique.The correlation between the p73 transcripts and response to remission-induction chemotherapy,relapse within 6 months was analyzed.Results There was no expression of p73 mRNA in 26.5% of patients with ALL.No expression of p73 mRNA was significantly associated with the treatment effect and relapse.Conclusion The p73 gene inactivation may play an important role in the development of ALL in children.Examination of p73 mRNA might have clinical significance in prognosis of ALL in children.
作者 殷小成 曹励之 张朝霞
机构地区 南华大学附一医院 中南大学湘雅医院
出处 《实用癌症杂志》 2003年第3期240-241,244,共3页 The Practical Journal of Cancer
关键词 儿童 急性淋巴细胞白血病 P73基因 基因失活 反转录聚合酶链反应 p73 gene Gene inactivation Acute lymphoblastic leukemia(ALL) Children
分类号 R733.71 [医药卫生—肿瘤]
  • 相关文献

参考文献7

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二级参考文献10

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共引文献323

同被引文献14

  • 1殷小成,曹励之,张朝霞,王颖超.p73 mRNA在急性淋巴细胞白血病细胞中的表达及其临床意义[J].中华儿科杂志,2004,42(7):529-530. 被引量：3
  • 2全国白血病化疗治疗讨论会.急性白血病疗效标准[J].中华血液学杂志,1988,9(3):183-183.
  • 3Kaghad M,Bonnet H,Yang A,et al.Monoallelically expressed gene related to p53 to 1p36 a region frequently deleted in ne oblashona and other human cancer[J].Cell,1997,90(4):809-819.
  • 4Scaniffi P,CascianoJ,Masiero L,et al.Lack of p73 expression in mature B-All and identification of three new splicing variants restricted to pre B and C-ALL indicate a role of p73 in B cell ALL differentiation[J].Leukemia,2000,14(3):518-525.
  • 5Corn PG,Kuerbiitz SI,Van Noesel MM,et al.Transcriptioral silencing of yhe p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with5'CpG island methylation[J].Cancer Res,1999,59(14):3 352-3 356.
  • 6Kawano S,Miller CW,Goinb art AF,et al.Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation[J].Blood,1999,94(3):1 115.
  • 7Mingli liu.Taketani Loss of p73 gene expression in lymphoid leukemia cell lines is associated with hypermethylation[J].Leukemia Research,2000,25(6):441-447.
  • 8Kaghad M,Bonnet H,Yang A,et al.Monoallelically expressed gene related to p53 to 1p36 a region frequently deleted in ne oblashona and other human cancer[J].Cell,1997,90(4):809～819.
  • 9Scaniffi P,Casciano J,Masiero L,et al.Lack of p73 expression in mature B-All and identification of three new splicing variants re-stricted to pre Band C-ALL indicate a role of p73 in B cell ALL differentiation[J]Leukemia,2000,14(3):518～525.
  • 10Com PG,Kuerbiitz SI,van Noesel MM,et al.Transefiptioral silencing of yhe p73 gene in acute lymphoblastie leukemia and Burkitt's lymphoma is associated with5 CpG island methylation[J].Cancer Res,1999,59(14):3352～3356.

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实用癌症杂志
2003年 第3期

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