上皮性卵巢癌危险因素的病例—对照研究

Case-control study on risk factors of epithelial ovarian cancer

目的:调查卵巢癌发病的危险因素,为预防卵巢癌的发生提供依据。方法:选择山东省19所地市以上综合医院住院、病理确诊的307例上皮性卵巢癌患者为病例组,同期住院的非恶性肿瘤患者307例为对照组,采用1:1配对设计,作条件logistic回归分析。结果:受过教育、经济状况好、多食肉类、甜食及脂肪、大便不规律、便秘、接触有害物质、精神抑郁、焦虑、精神紧张、性格急躁、精神创伤是卵巢癌发病的危险因素。而文盲、多食蔬菜水果、性格温和是降低卵巢癌发病危险的因素。单因素logistic回归分析后建立的多因素回归方程为:Y=-1.2856S17+1.9743S18-1.5918S38+1.4828S40。结论:多种因素影响卵巢癌的发生发展过程。

Objective:To estimate the risk factors of ovarian cancer and provide proof for pre-venting ovarian cancer.Methods:In a case-control1:1match study307patients with epithelial ovarian cancer were matched with307patients suffering from other diseases.The data were analyzed through conditional significant logistic regression.Results:The risk factors of ovarian cancer were acceptance of education,the high income,high meat,sweet food and fat consumption,irregular defecation,constipa-tion,touch with poisons,depression,anxiety,impatience,stress,and mental trauma,while other factors such as illiteracy,high vegetable and fruit assiumption,mild temper decreased the risk of ovarian can-cer.Con clu sion:The etiology of ovarian cancer is multifactorial and no evidence shows any single etio-logic factor for ovarian cancer.