盐酸奈法唑酮的合成

Synthesis of Nefazodone Hydrochloride

以苯酚为原料 ,先经加成、肼解、重排、缩合及环合反应合成 5 -乙基 -4 -(2 -苯氧基乙基 ) -2 H -1,2 ,4-三唑 -3(4 H ) -酮 ,再与哌嗪衍生物缩合 ,最后与盐酸成盐制得盐酸奈法唑酮 ,总收率 10 %。

Nefazodone hydrochloride was synthesized from phenol by addition, hydrazinolysis, re arrangement, condensation and cyclization to give 5 ethyl 4 (2 phenoxyethyl) 2 H 1,2,4 triazol 3(4 H ) one, which condensed with piperazine derivative and then salt formation in an overall yield of 10%.