重型肝炎患者血清sCR1与肝功能损伤程度的相关性研究

Relationship between the serum complement receptor 1 of patients with hepatitis gravis and the degree of liver damage

研究重型肝炎患者血清sCR1浓度的变化 ,探讨其临床意义。采用酶联免疫吸附法 ,对 3 0例重型肝炎、46例慢性病毒性肝炎及 3 0例正常人群红细胞研究表明 ,重型肝炎及慢性病毒性肝炎患者血清sCR1浓度均高于正常对照人群 (P <0 0 1) ,但重型肝炎患者血清sCR1浓度升高的幅度明显大于慢性病毒性肝炎患者 (P <0 0 1) ,并与CHE、PT及PTA的变化明显相关。重型肝炎患者血清sCR1浓度的变化与肝功能损伤程度密切相关 ,该指标可作为分析重型肝炎患者病情严重程度。

To study the changes and the clinical significance of serum complement receptor 1 (sCR1)of patients with hepatitis gravis. Enzyme-linked immuno-sorbent assay (ELISA) was used to analysis 30 cases with hepatitis gravis, 46 cases with chronic viral hepatitis and 30 control cases. It suggested that sCR1 of patients with hepatitis gravis or chronic viral hepatitis was significantly higher than that of the control group (P<0.01). And sCR1 of patients with hepatitis gravis was significantly higher than that of patients with chronic viral hepatitis (P<0.01),and was related with the changes of CHE, PT and PTA. It was concluded that the changes of sCR1 of hepatitis gravis was related with the damage degree of liver function, and it can be used as reference marker for analyzing of the degree of hepatitis gravis and judging the development and prognoses.