高渗氯化钠溶液对创伤性休克大鼠的治疗作用

Therapeutic effect of hypertonic saline solution on traumatic shock in rats

目的 探讨高渗氯化钠溶液复苏在创伤失血性休克治疗中的意义及其机制。方法 建立创伤性休克动物模型 ,随机分为对照组、处理组 ,处理组给予 7 5 %的高渗氯化钠溶液复苏 ,于休克末及给液后 1、3h测定骨骼肌、肝、小肠的组织氧分压 ,并测定给液后 2h后肺含水量变化 ,监测生命体征 ,记录存活时间。结果 复苏后处理组平均动脉压及肝脏、小肠的组织氧分压较对照组高 ,差异有显著性 (P <0 0 5 ) ,给液后 2h处理组大鼠肺含水量较对照组明显下降 ,差异有显著性 (P <0 0 5 ) ,处理组大鼠 1 2、2 4h存活率同对照组相比均有显著性差异。结论 高渗氯化钠溶液复苏可改善内脏器官的组织氧分压 ,减轻肺水肿 。

Objective To evaluate the effect of hypertonic saline solution on traumatic shock resuscitation in rats and explore the possible mechanisms.Methods Rat models of traumatic shock were established in Sprague-Daulay rats,which were randomly divided into two groups: control group and treatment group received 7 5% hypertonic saline to resuscitate. The oxygen partial pressure in the tissues from the skeletal muscles,liver and small intestine were measured at telophase of shock and 1,3 h after treatment.Hydrate volume in lung was detected at 2 h after resuscitation.Meanwhile,the hemodynamics of the rats and their survival rates at 12 adn 24 h were recorded.Results The changes of mean arterial blood pressure and oxygen partial pressure in the liver and small intestine of both groups were statistically significant after resuscitation(P<0 05).Hydrate volume in lung at 2 h after resuscitation was significantly lower in the treatment group than in the non-treatment shock group(P<0 05),while the survival rates at 12 and 24 h were also significantly different between two groups(P<0 05).Conclusion Hypertonic saline resuscitation could improve oxygen partial pressure of internal organs,lighten pulmonary edema and significantly increase the survival rate of rats with traumatic shock.