前列腺特异性膜抗原表达的临床意义

Prostate specific membrane antigen expression of prostatic adenocarcinoma and the relationship between PSMA expression and histologic grade

目的 探讨前列腺特异性膜抗原 (PSMA)在前列腺癌 (PCa)组织中的表达及与肿瘤病理分级之间的关系。 方法 采用免疫组化ABC法 ,用PSMA单克隆抗体对前列腺不同病变组织及非前列腺肿瘤组织石蜡包埋切片进行染色。其中PCa 70例 ,前列腺上皮肉瘤 2 1例 ,良性前列腺增生2 0例 ,其他肿瘤组织标本 30例。 结果 PSMA在 97%前列腺癌、10 0 %前列腺上皮内瘤、80 %BPH组织中呈不同程度的阳性表达 ,且在PCa组织中呈明显高表达 ,非前列腺肿瘤组织染色均呈阴性。组织PSMA表达与PCa组织学分级之间存在负相关性。 结论 PSMA具有良好的组织器官特异性 ,能够判断PCa预后 ,在PCa的免疫治疗方面具有应用前景。

Objective To investigate the relationship between PSMA expression and histologic grading of prostatic carcinoma. Methods Different prostatic tissues and non-prostatic tumors (PCa 70,prostate intraepithelial tumor 21,BPH 20,nonprostatic malignancies 30) were analysed for the expression of PSMA by using PSMA mono-clonal antibody and ABC immunohistochemical staining. Results All prostatic tissues but 2 cases of prostatic carcinoma and 4 cases of benign prostate hyperplasia were stained positively,while all of the non-prostatic tumors were stained negatively.There was a negative correlation between PSMA expression and histologic grading of prostatic adenocarcinoma. Conclusions PSMA was prostatic organic specific and could be a prognostic marker of prostate adenocarcinoma.