血清胆红素水平与高脂血症及动脉粥样硬化性疾病的关系研究

Investigation of relation and significance between serum bilirubin level and atherosclerosis diseases and hyperlipemia

目的 :探讨病人血清胆红素 (TB)水平与高脂血症及动脉粥样硬化性疾病的关系与意义。方法 :用改良J—G法检测病人血清中TB水平。结果 :高脂血症TB水平 (6 .40± 1 .2 3) μmol·L- 1 明显低于正常对照组 (1 2 .37± 5 .1 6) μmol·L- 1 ,TB水平随三酰甘油 (TG)、总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL -C)升高而减低 ,呈负相关 (r=- 0 .88,- 0 .89,- 0 .94) ;与高密度脂蛋白胆固醇 (HDL -C)呈正相关 (r=0 .94)。动脉粥样硬化性疾病病人血清中TB水平 (7.1 3± 2 .2 ) μmol·L- 1 比正常对照下降42 %～ 45 %。结论 :高脂血症患者血清中低水平TB可作为引起动脉粥样硬化性疾病的一个新的危险因素 ,如果与TG、TC、LDL -C和HDL -C等因素联合起来全面考虑 ,还可预测和判断动脉粥样硬化性疾病。

Objective : To investigate the relation and significance between serum bilirubin level and atherosclerosis diseases and hyperlipemia .Methods : Bilirubin level was detected by improved J-G method .Results: Bilirubin level of hyperlipemia patients(6.40±1.23)μmol·L -1 was lower than that of normal group (12.37±5.6) μmol·L -1 .There was a negative relation between bilirubin level with TG, TC, LDL-C ( r =-0.88,-0.89,-0.94) and a positive relation with HDL-C.The serum bilirubin level of atherosclerosis patients was lower 42%-45% than that of normal group.Conclusion: Low serum bilirubin level of hyperlipemia patients is a new risk factor ,it can judge and forecast atherosclerosis diseases if we jointly take TG, TC, LDL-C, HDL-C factors into consideration.