期刊文献+

TGF-β_1及其在胰腺纤维化中的作用

下载PDF
导出
摘要 慢性胰腺炎(chronic pancreatitis,CP)典型的病理表现为胰腺实质纤维化、腺泡细胞萎缩、胰管狭窄或扩张、胰管结石以及炎症细胞浸润。胰腺纤维化的本质是以胶原为主的细胞外基质(extracellular matrix,ECM)合成增多,而降解相对减少,两者失去动态平衡,致使过多ECM沉积。目前认为,在胆道梗阻、酒精、代谢、遗传等因素作用下。
出处 《胰腺病学》 2003年第2期118-120,共3页 Chinese JOurnal of Pancreatology
  • 相关文献

参考文献18

  • 1Massague J. TGF-β1 signal transduction. Annu Rev Biochem,1998, 67:753-791.
  • 2Piek E, Heldin CH, Dijke PT. Specificity, diversity, and regulation in TGF-β superfamily signaling. FASEB J, 1999,13:2105-2124.
  • 3Knittel T, Janneck T, Muller T, et al. Transforming growth factor beta-1 regulated gene expression of Ito cells.Hepatology, 1996,24 : 352-360.
  • 4Border WA, Noble NA, Yamamoto T, et al. Natural inhibitor of transforming growth factor beta protects against scarring in experimental kidney disease. Nature, 1992,360 : 361-364.
  • 5Kruse ML, Hildebrand PB0 Timke C, et al. TGFbeta1 autocrine growth control in isolated pancreatic fibroblastoid cells/stellate cells in vitro. Regul Pept, 2000,90 : 47-52.
  • 6Haber PS, Keogh GW, Apte MV. et al. Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis. Am J Pathol, 1999,155:1087-1095.
  • 7Schneider E, Schmid Kotsas A, Zhao J, et al. Identification of mediators stimulating proliferation and matrix synthesis of rat pancreatic stellate cells. Am J Physiol Cell Physiol, 2001,28:C532-543.
  • 8Dijke P, Miyazono K, Heldin CH. Signaling inputs converge on nucler effectors in TGF-β signaling. TIBS, 2000,25 : 64-70.
  • 9Apte MV, Haber PS, Darby SJ, et al. Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut, 1999,44 : 534-541.
  • 10De Bleser PJ0 Niki T, Rogiers V0 et al. Transforming growth factor-beta gene expression in normal and fibrotic rat liver. J Hepatol, 1997, 26:886-893.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部