外周电刺激抑制大鼠吗啡条件性位置偏爱的复发及海洛因成瘾者的心瘾(英文)

Inhibition by peripheral electric stimulation of the reinstatement ofmorphine-induced place preference in rats and drug-craving in heroin addicts

目的 :探讨外周电刺激 (PES)是否能频率依赖性地抑制吗啡条件性位置偏爱 (CPP)的复发和抑制海洛因成瘾者脱毒后的心瘾。方法 :用二室自动CPP箱记录大鼠条件性CPP ,用视觉模拟尺测量海洛因成瘾者的“心瘾(渴求 )”。结果 :(1)低频PES能抑制大鼠小剂量吗啡点燃、或脚底电刺激诱发的吗啡CPP ;(2 )上述效应可被小剂量吗啡受体拮抗剂纳洛酮 (1mg·kg-1)翻转 ,提示有内源性阿片机制参与 ;(3)低频PES还能使海洛因成瘾者脱毒后对毒品“心瘾”的自然消退过程加速。结论

Objective:To test the hypothesis that peripheral electric stimulation (PES) may suppress the reinstatement of morphine induced conditioned place preference (CPP) in rats as well as the drug craving of detoxified heroin addicts in a frequency dependent manner.Methods:CPP model of the rat was constructed with two compartment automatic CPP apparatus, and the craving of the heroin addicts was assessed with a visual analogue scale (VAS). Results:(1) PES of low frequency could prevent the drug priming or foot shock induced reinstatement of morphine CPP; (2) this effect was naloxone reversible, suggesting a possible involvement of endogenous opioid mechanisms; and (3) PES of low frequency could also accelerate the rate of natural decay of drug craving in heroin addicts after successful abstinence. Conclusion:PES might serve as a therapeutic measure for the treatment of heroin addiction.