正常老年人计算任务的脑功能磁共振成像研究

The fMRI study of the calculation tasks in normal aged volunteers

目的 :探讨正常老年人进行脑功能磁共振成像 (fMRI)实验的可行性及计算任务的激活脑区。方法 :对11例正常老年志愿者进行简单计算任务和复杂计算任务的fMRI实验 ,以SPM99作后处理显示激活脑区。结果 :11例被试的简单计算任务均完成较好 ,激活区域主要集中在双侧顶上、下小叶和双侧枕叶 ,复杂计算任务除了以上脑区的激活外 ,还包括Brodmann 9、10区和Brodmann 4 6区。结论 :老年人进行fMRI实验具有可行性 。

Objective: To investigate the feasibility and cortex activation of fMRI in aged volunteers during the performance of calculation tasks. Methods: Internal mental calculation tasks including simple tasks and complicated tasks were conducted in 11 normal aged volunteers. The fMRI data was postprocessed using SPM99 to reveal the activated cortex. Results: The simple calculation tasks were fulfilled satisfactorily in all aged subjects. Cortex in the bilateral Superior parietal lobule, inferior parietal lobule and bilateral occipital lobes showed activation. We found a selective enhancement of fMRI signal in Brodmann regions 9, 10 and 46 in the complicated tasks. Conclusion: fMRI tasks are feasible in aged people and more cortex of the left frontal lobe shows activation in complicated calculation tasks.