摘要
寻常痤疮是一种毛囊、皮脂腺的慢性炎症 ,为探讨消痤洁肤乳膏治疗寻常痤疮的疗效 ,治疗组 (5 9例 )给予消痤洁肤乳膏外搽 ,对照组 (30例 )用不含有效成份的乳膏基质外搽 ,同时检测两组患者治疗前后血清白介素 (IL) - 1α、IL - 6、IL - 8和α-肿瘤坏死因子 (TNF -α)的水平。结果发现治疗组疗效明显优于对照组 ,且不良反应少。两组痤疮患者治疗前的前述四种细胞因子水平均高于健康人 ,而治疗组在治疗后各因子与健康人相比无显著性差异。提示消痤洁肤乳膏可能通过抑菌、减少皮脂分泌、降低细胞因子水平等多个环节达到治疗寻常痤疮的作用 。
Acne vulgaris is a kind of chronic inflammation of follicle and sebaceous gland, the effectiveness of Xiao Cuo Jie Fu Cream for acne vulgaris was investigated by the randomized controlled clinical test. Xiao Cuo Jie Fu Cream was given to 59 patients in the treatment group,twice a day for 4 weeks,and the only the basement of Xiao Cuo Jie Fu Cream was given to 30 patients in the control group,twice a day for 4 weeks. The Changes of skin lesions was observed and documented, and the serum level of interleukin (IL)-1α,IL-6,IL-8 and α-tumor necrosis factor (TNF-α) were tested before and after treatment. The treatment groups were recovered better than that of the control group with little adverse effect. The higher serum level of the tested 4 cell factors compared with health standard descent after treatment, which suggested the mechanism of Xiao Cuo Jie Fu Cream might be related to its impact on inflammatory cell factors. Xiao Cuo Jie Fu Cream was worthy in treating acne vulgaris and its therapeutic effects might be through several ways such as reducing cellular factors.
出处
《华西医学》
CAS
2003年第2期183-184,共2页
West China Medical Journal