氧化苦参碱治疗肝纤维化临床疗效观察

Clinical effect observation effect of oxymatrine to liver fibrosis in chronic hepatitis

目的:观察氧化苦参碱对慢性肝炎患者抗肝纤维化的作用。方法:使用氧化苦参碱治疗60例慢性肝炎患者,前后进行血清肝纤维化标志物检测。结果:慢性肝炎中,中、重度患者经氧化苦参碱治疗,3月后血清标志物明显下降,有显著差异,P<0.01,而慢性肝炎轻度肝硬化患者无显著差异。结论:氧化苦参碱对慢性肝炎患者有明显的抗肝纤维化作用。

Objective To observe the effect of oxymatrine to liver fibrosis in chronic hepatitis.Meth od Before and after oxy-matrine treatment of 3months,the serum concentrations of liver fibrosis markers in60cases with chronic hepatitis were detected and compared.Results After the treatment course of 3months by oxymatrine,the serum levels of liver fibrosis markers were de-creased significantly in cases with moderate and severe type(P<0.01).While the differences in cases with mild type and liver cir-rhosis were not obvious statistically.Conclusion Oxymatrine has remarkable effect to liver fibrosis in chronic viral hepatitis with mod-erate and severe type.