安钠咖体外对人精子活力的影响

THE EFFECT OF CNB ON HUMAN SPERMATOZOAL MOTILITY AND SUYVIVAI RATE IN VITRO

cAMP 在精子的鞭毛运动中有重要作用,可影响精子的活动力和存活率。体外实验结果表明:当安钠咖(CNB)浓度为7.36—29.45mmol/L 时,可明显改善精子的活动力,提高精子的存活率。尤以浓度为14.73mmol/L 时效果最佳。当精液排出11小时,对照组精子活动力为O—I 级,存活率为22.85%时,14.73mmol/L 浓度组的精子活动力仍为Ⅰ—Ⅱ级,存活率为46.27%。存活时间明显延长达5.27小时,P<0.001。最长延长达8小时。因此,认为对于部分男性不育症患者,通过性交前后阴道内给适当浓度的CNB 是有意义的。

The mechamism of action of CNB is cAMP concentration increasein the cells.The cAMP can influence psermatozoal motility and SnrvivalrateThe results showea that when CNB concentraion was 7.36—29.45 mmol/L,spermatozalmotility were improved andSuxvival rate were are inereased.When concentration was14.73mmol/L,effect is the best.When semen are excreted for 11 hours,spermatozoalMotility is O—I and spermatozoal Survival rateis 22.85% in the contralgroup,but spermatozoal motility is Ⅰ—Ⅱ grade and spermatozoal rate was 46.27%in 14.73mmol/L group,while spermatozoal Survivuel time prolong for 5.27 hours.P〉0.001.Upper limit—8 hours.Therefore infertility men Wre treated by properconcentration CNB in vagina.