肾综合征出血热心肌酶谱和心肌肌钙蛋白I的动态检测

The Changes of Serum Myocardial Enzymes and Cardiac Troponin I in Hemorrhagic Fever with Renal Syndrome and Its Significance

目的 研究肾综合征出血热患者各病期心肌酶谱和心肌肌钙蛋白I(cTnI)的动态变化及临床意义。方法 使用美国EKTACHEM 75 0XRCAnalyzer生化分析仪测定对肾综合征出血热患者各病期天冬氨酸氨基转移酶 (AST)、磷酸肌酸激酶 (CK)及其同工酶 (CK MB)、乳酸脱氢酶 (LDH)和α 羟丁酸脱氢酶 (α HBDH)进行测定 ,cTnI采用杭州埃夫朗生化制品有限公司试剂盒测定。结果 与对照组相比 ,在发热期仅AST、LDH和cTnI有显著性变化 ,其他指标变化不显著 ;低血压休克期AST、LDH和CK MB活性最高 ,其他指标差异显著 ;少尿期CK、α HBDH和cTnI变化达到高峰 ;多尿期AST出现一个新的高峰 ;恢复期除AST、cTnI外 ,其余指标均恢复正常。结论 对肾综合征出血热患者心肌损伤相关指标的测定有助于肾综合征出血热的诊断。

Objective To evaluate the significance of serum myocardial enzymes and cardidc troponin I in hemorrhagic fever with renal syndrome (HFRS). Methods Myocardial enzymes (AST,CK,CK MB,LDH,α HBDH) and cardidc troponin I (cTnI) dynamically measured in patients with HFRS. Results The activity of AST and LDH and concentration cTnI increased significantly since febile phase.The highest phase of AST,LDH,cTnI was hypotensiveshook phase,and of CK,α HBDH and cTnI was oliguria phase.The level of the parameters all returned to normal in convalescent phase except AST and cTnI. Conclusion The results indicate that dynamic measurement of serum myocardial enzymes and cardidc troponin I may be valuable in estivesting the situation in patients with HFRS.