摘要
目的 探讨放射治疗中获得最大肿瘤控制概率 (TCP )的剂量分布。方法 在假设肿瘤部位治疗能量一定的情况下 ,根据提出的TCP计算模型 ,用拉格朗日乘子方法推导出任意肿瘤生物学参数取值分布时获得最大TCP的条件。在假设的生物学参数取值和分布下 ,通过计算画出最佳剂量分布和剂量均匀分布时TCP与肿瘤中平均剂量的关系曲线进行分析。结果 在参数取值分布不均匀时 ,最佳剂量分布时TCP与肿瘤中平均剂量的关系曲线要好于剂量均匀分布时的曲线 ,而且随着参数取值不均匀性的增加 ,两者的差距变大。
Objective To analyze what kind of dose distribution can lead to the optimum tumor control probability(TCP).Methods When the total absorbed energy was defined,with the proposed TCP model and the method of Lagrange multiplier,the condition which can cause the optimum TCP will be derived.With the assumed values of biological parameters,the curves of the relationship between TCP and the averaged dose in the tumor for the uniform or optimum dose distribution will be shown respectively by calcultion.Results When the values of biological parameters are not uniform in the tumor,the TCP and average dose relationship curve of optimum dose distribution is better than that of uniforn dose distribution.Conclusion The dose distribution that can cause the optimum TCP is related to the distribution of the biological parameter values.
出处
《中国辐射卫生》
2003年第2期70-71,共2页
Chinese Journal of Radiological Health
基金
国家自然科学基金资助项目 (39670 2 2 8)
