强迫跑步等复合因素对Wistar大鼠左心室血流动力学的影响

Influence of Complex Factors on Left Ventricle Haemodynamics of Wistar Rat

目的 检测控食、强迫跑步及大剂量心得安等复合因素对Wistar大鼠左心室血流动力学的影响。方法 实验组实验全过程采用控食及强迫跑步的方法造模 ,第 17天起每日灌服心得安溶液 ,连续 4d。第 2 1天测定血流动力学。然后将余下的大鼠再平均分为药物反证组和鉴别反证组。药物反证组灌服补心气口服液 ,连续 12d。鉴别反证组灌服滋心阴口服液 ,连续 12d ,最后测定血流动力学。结果 实验组最大心室内压、平均 +dp dtmax、平均Vpm等指标均小于正常组 ,且差异有显著性。最小心室内压、平均 dp dtmax等指标均大于正常组 ,差异亦有显著性。结论 控食。

Objective\ To explore the effect on left ventricle haemodynamics of Wistar rat caused by complex factors including slimming, forced running and large dosage of propanolol.Methods Every animal in experiment group was forced to run with slimming. From 17th day ig propanolol was given and lasted for 4 days. At 21st day haemodynamics was measured in 6 rats. Then the rest rats were divided into supplement Qi group and nourishment Yin group. Supplement Qi group was given ig \%Buxinqi\% oral liquid for 12 days. Nourishment Yin group ig \%Zixinyin\% oral liquid for 12 days. In the end, haemodynamics measured.Results The indexes of experiment group such as intraventricular pressure max ,+dp/dtmax mean ,Vpm mean were less than those of control group significantly. The indexes of experiment group such as intraventricular pressure min ,-dp/dtmax mean were higher than those of control group significantly.Conclusion The complex factors including slimming, forced running and large dosage of propanolol could restrain the heart function of Wistar rat.