摘要
目的 探讨血小板膜糖蛋白Ⅱb、Ⅲa、(GPⅡb、Ⅲa)、Ⅳ (GPⅣ )在急性脑梗死中的变化。方法 应用流式细胞仪 (FCM)对 5 4例急性脑梗死患者发病后 1～ 3天及发病后 10～ 14天进行了血小板膜糖蛋白Ⅱb、Ⅲa、Ⅳ检测。结果 急性脑梗死患者发病后 1～ 3天内血小板膜糖蛋白Ⅱb、Ⅲa 及Ⅳ表达较对照组极显著增高 (P <0 .0 1)。发病后 10～ 14天的血小板膜糖蛋白Ⅱb、Ⅲa、Ⅳ表达较对照组极显著增高 (P <0 .0 1)。发病后 10～ 14天的血小板膜糖蛋白Ⅱb、Ⅲa、Ⅳ表达较发病后 1～ 3天极显著下降 (P <0 .0 1)。结论 血小板膜糖蛋白Ⅱb、Ⅲa、Ⅳ在急性脑梗死的发病过程中具有重要的作用。
Objective To observe the changes of platelet membrane glycoprotein Ⅱ b、 Ⅲ a、 Ⅳ.in peripheral blood in patients with acute cerebral infarction.Methods We measured the levels of platelet membrane glycoprotein Ⅱ b、 Ⅲ a、 Ⅳ in 54 patients during the Ist-3th day and the 10th-14th day after onset by flow cytometry.Results The levels of platelet membrane glycoprotein Ⅱ b、 Ⅲ a、 Ⅳ in peripheral blood in patients during both the 1th-3th day and the 10th-14th day after the onset were significantly higher than those of controls (P< 0.01).Conclusions This study shows that platelet membrane glycoprotein Ⅱ b、 Ⅲ a、 Ⅳ play an important role in the pathogenesis of acute cerebral infarction.
出处
《卒中与神经疾病》
2003年第3期165-168,共4页
Stroke and Nervous Diseases
