血管性痴呆神经心理学与事件相关电位的研究

The correlation between neuropsychology in vascular dementia and event-related potentials

目的 探讨血管性痴呆神经心理学与事件相关电位 (P3 0 0 )的变化规律及临床意义。方法 选取血管性痴呆患者 30例 ,并以与其年龄、性别基本相似的体检健康者为对照组 ,用认知能力甄别检查法(CCSE)、老年性痴呆评定量表 (ADAS)作神经心理学测试后 ,再用听觉Oddball序列研究血管性痴呆患者事件相关电位 (ERPs)的P3 成分。结果 血管性痴呆组CCSE、ADAS与对照组有显著差异 (P <0 .0 5 )。血管性痴呆组P3 峰潜伏期 (P3 PL)、P3 波幅 (P3 AMP)与对照组相比差异显著 (P <0 .0 5 )。CCSE与P3 PL呈显著负相关 (r =- 0 .35 7,P <0 .0 5 ) ,ADAS与P2 PL呈显著正相关 (r =1.2 5 ,P <0 .0 5 )。结论 血管性痴呆的认知功能评分与患者的P3 潜伏期长短有明显相关性。

Objective To explore the regulation of changes between neutopsychologly in vascular dementia and ERPs and its clinical significance. Methods 30 cases of vascular dementia were classfied as patient group and 30 normal subjects with corresponding age and sex as a control group, Neuropsychological examination included CCSE, ADAS and the component P 3 of ERPs in patients with vascular dementia was studied by autioddball sequencing and correlative analyses.Results The disparity between the two groups is notable (P< 0.05). P 3PL and P 3AMP in the patient group were significantly different from those in the control group (P< 0.005). CCSE and P 3PL showed notable negative correlation (r=-0.357, P< 0.05), and ADAS and P 3PL showed notable negative correlation (r=1.25,P< 0.05).Conclusions The correlation between the cognition function and P 3PL of the patients with vascular dementia is notable.