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羟基丁酸对放射性脑损伤的保护作用 被引量：4

The study on sodium gamma-hydroxybutyrate protect from the injury of radiothe rapy on brain tissues
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摘要 目的对γ-羟基丁酸钠联合放疗减少放射性脑损伤及其作用机理进行探讨研究。方法采用γ-羟基丁酸钠配合常规放疗对实验动物的脑损伤进行病理学观察,以Mistra肾上腺素自氧化法、Uchiyama试验分别测定SOD活力和LPO含量。结果γ-羟丁酸钠明显减少6MeVβ射线辐照后脑组织损伤,而且可提高SOD活力及减少LPO含量。结论γ-羟丁酸钠减少放射性脑组织损伤、缓解放疗反应,在提高脑胶质瘤放射治疗效果中发挥着重要作用。 Objective The protective effects and pathophysiological mechanis m of sodium gammahydroxybutyrate (GHB) on rat brain tissues treated by photon rays were studied. Methods The rat brains were treated through GHB combined with 6 M ev 猓璸hoton rays, and Lipid peroxide (LPO) and Superoxide dismutase (SOD) were measured by Mistra′and Chiyama′tests. Results GHB could reduce obviously necr osis cell counts in CAI region of hippocampus. Meanwhile GHB enhance the activit ies of SOD and decreased the contents of LPO in the cerebrum after irradiation w ith 6 Mev 猓璸hoton rays too. Conclusion The results demonstrated that sodium g amma-hydroxybutyrate could play an important role in reducing the extent of rad iation damage of normal brain tissues and relieving the side effects of radiothe rapy on rats.
作者 楚建军 苏燎原 许昌韶 谢其根 章国芬 周菊英 王震吾 刘芬菊
机构地区 苏州大学附属第四医院 苏州大学核医学院 苏州大学附属一院
出处 《中国航天医药杂志》 2003年第2期1-3,共3页 Medical Journal of CASE
基金 苏州大学科技基金资助项目(200012)
关键词 γ—羟基丁酸钠 放射性脑损伤 脑保护 放射治疗 脂质过氧化物 超氧化物歧化酶 试验 Gamma-hydroxybutyrate (GHB) Radiation therapy (RF) Lipid peroxid e (LPO) Superoxide dismutase (SOD) Gliomas
分类号 R818 [医药卫生—放射医学]
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参考文献12

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同被引文献21

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引证文献4

二级引证文献3

中国航天医药杂志
2003年 第2期

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