摘要
目的探讨盐酸川芎嗪体外抗氧化作用。方法采用红细胞自氧化溶血、H2O2所致红细胞氧化溶血,肝匀浆MDA生成和Fe2+诱导的肝匀浆MDA生成,用比色法测定。结果盐酸川芎嗪体外给药能明显抑制家兔红细胞自氧化和H2O2所致红细胞溶血,并抑制肝匀浆自发性和Fe2+诱导的脂质过氧化反应。结论盐酸川芎嗪具有体外抗氧化作用,对红细胞和肝组织细胞具有膜保护作用。
Objective To study the effects of antioxidative activities of li gu strazine in vitro.Methods The hemolysis of red blood cells by itself and H2O2,MD A production in liver homogenate or induced by Fe2++VitC were measured by colo rimetric assay.Results Ligustrazine exhibited a significant potency in inhibitin g rabbit erythrocyte hemolysis (P<0.01) and lipid peroxidation in rabbit liver h omogenate (P<0.01).Conclusion These results indicate that ligustrazine has a pro tective activity for the membranes of erythrocytes and tissue cells of liver. Li gustrazine possessed an antioxidant activity.
出处
《中国航天医药杂志》
2003年第2期37-39,共3页
Medical Journal of CASE
