有创通气与无创通气治疗慢性阻塞性肺病并急性呼吸衰竭疗效比较

Comparison of the Effect of Invasive Ventilation and Noninvasive Ventilation in Treatment of Acute Respiratory Failure in Chronic Obstructive Pulmonary Disease

目的:探讨有创通气和无创通气治疗慢性阻塞性肺病(COPD)并急性呼吸衰竭的疗效。方法:将COPD并急性呼吸衰竭患者22例分为两组,分别给予有创通气和无创通气治疗。通气前和通气后第12、24、48小时分别查动脉血PaO_2和PaCO_2,比较两种通气方法的疗效。结果:有创通气能明显提高PaO_2,降低PaCO_2,总有效率为100%;而无创通气仅能轻度提高PaO_2,无法降低PaCO_2,总有效率仅为27%。两组比较差异有非常显著性意义(P<0.01)。结论:有创通气治疗COPD并急性呼吸衰竭的疗效明显优于无创通气。

Purpose: To compare the effect of invasive ventilation and noninvasive ventilation in treatment of acute respiratory failue in chronic obstructive pulmonary disease( COPD). Methods: 22 cases of COPD were randomly divided into two groups. The treatment group was given invasive ventilation, the control group was given non-invasive ventilation. PaP2 and PaCO2 of artery blood were meassured before ventilation and at 12,24,48 hours after ventilation,the results of both groups were compared. Results: Invasive ventilation could significantly increase the PaO2 and decrease the PaCO2 ,its total effective rate was 100%. Non-invasive ventilation just slightly increased the PaO2 and could not decrease the PaCO2, its total effective rate was 27% . The difference between the two methods was significant(P<0.01). Conclusion: It is suggested that invasive ventilation is better than non-invasive ventilation.