超早期静脉溶栓治疗急性脑梗死临床研究

Intravenous Thrombolysis for Acute Cerebral Infarctions with in 6h from Symptom Onset

目的:评价超早期应用尿激酶溶栓治疗急性脑梗死的疗效及安全性。方法:采用尿激酶(100万u～150万u/人次)超早期治疗急性脑梗死溶栓组30例,并设立同期对照组29例。在治疗前后对临床疗效(神经功能缺损评分、日常生活能力状态评分)、并发症、CT等方面进行比较分析。结果:与对照组比较,溶栓组在不同时间的治疗显效率都明显增高(P<0.05)。治疗组并发脑出血2例,1例因左额顶叶出血并发脑疝死亡(死亡率为6.64%);对照组并发梗死后出血1例,因大面积脑梗死并发脑疝死亡2例(死亡率为6.9%)。结论:超早期(6小时以内)静脉溶栓治疗急性脑梗死疗效明显,是一种有效、安全的治疗方法。

Purpose: To evaluate the clinical efficacy and reliability of urokinase in the treatment of acute cerebral infarctions within 6h from symptom onset. Methods: Thirty patients with acute cerebral infarction were treated with urokinase with in 6h from symptom onset,29 patients were the control group treated by compound injection of salvia. The curative effects and complications have been observed. Results:The effective rate in the experimental group was higher than that in the control group. Statistical difference was found between the two groups. There was no difference in the incidence of complications between the two groups. Conclusion: Trombolytic therapy within 6h from symptom onset could result in good clinical effects and safety in the treatment of acute cerebral infarction.