肿瘤相关物质群联合检测对肺癌转移的临床诊断价值

Levels of tumor supplies group of factors (TSGF)in the metastasis of lung cancer

目的 探讨肿瘤相关物质群 (TSGF)对肺癌转移和复发的诊断价值。方法 采用福建新大陆生物技术有限公司生产的TSGF快速检测诊断试剂盒对临床确诊的 75例肺癌患者 (其中局限组 39例 ,远转组 36例 )及 2 4例健康对照者血清TSGF含量进行检测 ,以TSGF≥ 6 4U/ml判断为阳性。结果 肺癌患者血清TSGF水平为 77.0 8± 15 .73U/ml( x±s) ,阳性率为 88% ,与正常对照组的 5 9.4± 4 .4 5U/ml( x±s)相比有显著差异 (P <0 .0 1)。远转组的肺癌患者的血清TSGF水平为 88.2 2± 15 .6 9U/ml,阳性率 97% ,与局限组肺癌的 6 7.5 6± 7.4 3U/ml相比亦有显著性差异 (P <0 .0 1)。结论 血清TSGF测定对肺癌的诊断有高度敏感性和特异性 。

Objective To determine the clinical diagnosis value of tumor supplies group of factors (TSGF)in the metastasis and relapse of lung cancer.Methods TSGF was measured by spectrophotometry in 24 healthy subjects and 75 patients with lung cancer (39 cases of localized tumors and 36 cases of distant metastasis).The positive bordline of serum TSGF was 64U/ml in our hospital.Results The level of serum TSGF in lung cancer group was 77.08±15.73U/ml( ±s ),its positive rate was 88%,the controls was 59.4±15.69U/ml and 8.3%, the TSGF value and its positive rate in distant metastasis cancers was 88.22±15.69U/ml and 97%,the TSGF value and its positive rate in localized cancers was 67.56±7.43U/ml ( P <0.01) and 79%.Conclusion The serum TSGF level is a highly sensitive and specific marker in the diagnosis of lung cancer,especially for distant metastases.