米索前列醇用于足月妊娠引产的效果分析

The effects of misoprostol on cervical ripening and labor induction

目的 :探讨米索前列醇用于足月妊娠引产的安全及效果。方法 :将 1 1 0例有引产指征的孕足月单胎头位、无宫缩的初产妇 ,随机分成两组 ,研究组 (5 4例 )用米索前列醇 5 0 μg阴道用药 ,每 3小时 1次至正式临产 ;对照组 (5 6例 )用蓖麻油鸡蛋餐口服。结果 :用药后宫颈Bisshop评分研究组由原 5 98分提高至 9 4 8分 ,对照组由原 6 1 6分提高至 8 5 5分 ,两组宫颈Bisshop评分均变化 ,相比有极显著差异 (P <0 0 0 1 ) ,用药至分娩时间 ,研究组为 9 0小时较对照组为 1 4 4小时明显缩短 (P <0 0 0 1 ) ,自然分娩率研究组为 96 % ,对照组为 85 7% (P >0 0 5 ) ,产后出血 ,新生儿Apgar评分及用药副作用等两组相比均无显著差异(P >0 0 5 )。结论 :米索前列醇用于足月妊娠引产能促宫颈成熟及发动子宫收缩 ,是安全。

Objective:To study the safety and efficacy of misoprostol on labor induction.Methods:110 patients with an indication for induction of labor were randonly assigned to two groups(54 cases and 56 cases),one induction with misoprotol, 50μg intravavaginally every 3 hours until active labor,the other with ricinus oil meal.Results:The Bisshop score difference was of great significance between the two groups in favour of misoprostol,changing from 5 98 to 9 48 versus 6 16 to 8.55 Mean induction to delivery interval was 9 0 hours in the study group,and 14 4 hours in the controled group.(P<0 001).The success rate for vaginal delivery was significantly higher in the misoprostol group(96%) compared with the controled group(85 7%)(P>0 05),While neonatal Apgar scores at one and five minutes,postpartum hemorrhage and drug side effects were of no significance between the two grorps.Conclusions:Vaginally adiministrated misoprostol is an effective agent for the cervical ripening and induction of labor.