灵芝生料酿制液降血脂作用研究

Effect of Ganoderma Lucidum Brewage in Decreasing Blood Lipid

[目的]探讨灵芝生料酿制液的降血脂药理作用。[方法]采用蛋黄乳致高血脂小鼠模型和高脂饮食致高血脂大鼠模型,观察不同剂量的灵芝生料酿制液对两种高血脂模型的降血脂作用,并与血脂康、灵芝的传统剂型灵芝饮和灵芝胶囊作比较。[结果]灵芝生料酿制液可降低蛋黄乳致高血脂模型小鼠血清甘油三酯(TG)和胆固醇(CH)的含量(与模型组比较,P<0.05或P<0.01);可显著降低高脂饮食致大鼠高血脂症血清甘油三酯和胆固醇的含量(与模型组比较,P<0.05或P<0.01),而高密度脂蛋白(HDL-CH)的作用不明显。[结论]灵芝生料酿制液具有较好的降血脂作用,有望开发为新的降脂药物。

[Objective] To observe the pharmacological action of Ganoderma Lucidum Brewage (GLB) in decreasing blood lipid. [ Methods ] Eighty rats were randimized into 8 groups: blank control (Group A), model ( Group B) high-dose GLB ( Group C), moderate-dose GLB ( Group D), low-dose GLB ( Group E), Ganoderma Lucidum Decoction (Group F), Ganoderma Lucidum Capsule (Group G) and Xuezhi Kang (Group H). So did the mice. Hyperlipidemia mouse models and rat models were induced by yolk and high-fat diet respectively. Effect of GBL in various doses to decrease blood lipid was observed in the two kinds of hyperlipidemia models and was compared with that of Xuezhi Kang, Ganoderma Lucidum Decoction and Ganoderma Lucidum Capsule. [Results] GLB could decrease the serum contents of triglycerides and cholesterol both in model mice and model rats (P<0.05 or P < 0.01 as compared with those in model groups). GLB had no obvious effect on high-density lipoprotein cholesterol. [Conclusion] GLB exerts a good effect in decreasing blood lipid content and is expected to be a new drug for hyperlipidemia.