放射工作人员免疫功能检测分析研究

Study and anaylsis on the immunity function of radiation workers

目的 探讨长期低剂量电离辐射对放射工作者免疫功能的影响。方法 应用碱性磷酸酶抗碱性磷酸酶 (A PAAP)桥联酶标技术和单项琼脂扩散法分别对 5 0 0例放射工作人员的细胞免疫和体液免疫进行了检测分析 ,并对该组人群进行为期 1年的个人剂量监测 ,以确定其年有效剂量。结果 该组人群中年有效剂量 97 5 9%低于 5mSv ,CD3 、CD4和CD4/CD8比值均明显低于正常对照组 (P <0 0 1) ,表现为随工龄的增加而降低。体液免疫以放射组中IgG、IgA含量升高为特征 ,各年龄段放射组与对照组相比差异有显著性 (P <0 0 5 )。结论 提示低剂量电离辐射的照射虽可刺激B淋巴细胞分泌免疫球蛋白 ,但同时也可降低T淋巴细胞亚群CD3 、CD4和CD4/CD8的比值。

Objective To study the effect of long-term low-dose ionization radiation on worker's immune function. Methods 500 radiation workers were examined with cellular immunity and humoral immunity by APAAP and single diffusion. Results The results showed that the number of CD 3, CD 4 positive T lymphocytes and the ratio CD 4/CD 8 were significantly lower than those of the control group ( P <0.01) and appeared to be declined with the increase of working-years. The amount of IgA, IgG in all groups of pursuit aiming were significantly higher than those of controls ( P <0.05). It also showed that there was 97.59% of the radiation workers' annual effective doses less than 5 mSv. Conclusion It indicated that low-dose ionization radiation could stimulate B lymphocytes to secrete Ig and lower the number of CD 3, CD 4 positive T lymphocytes and the ratio of CD 4/CD 8.