银杏叶聚戊烯醇联合化疗药对Heps和EC荷瘤小鼠的抗癌作用

The effects on transplanted Heps and EC tumors in mouse for polyprenols in combination with chemotherapeutic drugs

目的研究聚戊烯醇联合化疗药对Heps和EC荷瘤小鼠的药效作用。方法从银杏叶中分离纯化聚戊烯醇 ,分别与氟脲嘧啶 (5 Fu)、环磷酰胺 (CTX)和顺铂 (PDD)联合应用 ,对移植性Heps和EC荷瘤小鼠进行抑瘤实验 ,并与 5 Fu、CTX和PDD单独用药比较。结果聚戊烯醇分别与CTX、PDD合用 ,对肝癌Heps的抑瘤率分别从4 2 .2 5 %、4 5 .0 4 %提高到 5 6 .4 9%、5 4 .96 % ;聚戊烯醇分别联合CTX、5 Fu用药 ,对艾氏腹水瘤EC的抑瘤率分别从37.6 4 %、39.89%提高到 6 2 .92 %、5 3.37%。

PurposeTo study the pharmacology in combination with chemotherapeutic drugs for polyprenols.MethodsPolyprenols separated and purified from ginkgobiloba L were administered alone and in combination with 5 Fu,CTX and PDD,and in contrast with 5 Fu,CTX and PDD alone,the experiments were carried out on mouse transplanted Heps and EC.ResultsCTX,PDD were adminstered alone and in combination with polyprenols respectively , the inhibination of Heps nodule was raised from 42.25% and 45.04% to 56.49% and 54.96% respectively,and combining CTX and 5 Fu with polyprenols,the inhibination for EC nodule was raised to 62.92% and 53.37% respectively from 37.64% and 39.89% in contrast with their administration alone.ConclusionPolyprenols have a significant effects on chemotherapeutic drugs and reduce their toxicity.