传统抗癫癎药物与托吡酯对成年癫癎患者生活质量影响的对比研究

Comparative study on quality of life in traditional anti-epileptic drug and topiramate treat for the patients with adults epilepsy

目的 探讨传统抗癫癎药物(AEDs)与托吡酯(TPM)对成年癫癎患者生活质量(QOL)的影响。方法 102例临床确诊的成年癫癎患者随机分为AEDs组和TPM组,井用QOL IE-30表对102例癫癎患者和62名正常人(对照组)进行评定。结果 AEDs组较对照组QOL明显降低(P<0.05),表现惧怕发作,对日常生活不满意,情绪差,精力不足,认知功能下降,对长期服用抗癫癎药物的顾虑较多,社交、工作受限等;而TPM组的QOL虽然低于对照组(P<0.05),但在前5项的评分中明显高于AEDs组(P<0.05)。TPM组的发作频率明显低于AEDs组(P<0.05)。发作频率对癫癎患者QOL的影响较大,癫癎发作越频繁,QOL越差。结论 成年癫癎患者的QOL较正常人显著降低,TPM能提高癫癎患者的QOL,其改善QOL的作用主要是通过控制发作实现的。因此,合适的药物控制癎性发作是提高癫癎患者QOL的关键。

Objective To explore the effect on quality of life in traditional anti-epileptic drug and topiramate(TPM) treat for the patients with adult epilepsy. Methods 102 patients with adults epilepsy by clinical diagnosed were randomly divided into two groups: AEDs (anti-epileptic drugs) group and TPM group. QOLIE-30 was used to evaluate 102 patients and 62 normal controls. Results QOL scores were lower in AEDs group compared with control group( P < 0.05) . The main manifestations included: worrying about the seizure attacks, being unsatisfied with daily life, being in a blue mood, easy to be tired, having memory problems, worrying about the effects of long-term antiepileptic medication and limitation in work and social activities. Though QOL scores of TPM group were lower than that of control group( P < 0.05), they were much higher than that of AEDs group in the first five subsets (P <0.05) .The seizure frequency of TPM group was much lower than that of AEDs group( P < 0.05) .Seizure frequency took an important part in QOL of epileptic patients. QOL was negatively associated with frequency. Conclusion The QOL scores of adults epilepsy is much lower than that of normal controls. TPM can improve the QOL of epileptic patients by means of controlling seizure frequency. It indicates that choosing the proper antiepileptic drugs to control seizure attack is the key factor to improve the QOL of epileptic patients.