谷慷太林对骨质疏松症患者骨密度和血清酶学的影响

Effect of Gukuangtailing on Bone Density and Serum Enzyme of Osteoporosis Patients

目的 :观察谷慷太林注射液对原发性骨质疏松症患者骨密度和血清酶学的影响。方法 :5 8例患者配伍分为 2组 ,A组 2 8例每天静滴谷慷太林骨肽注射液 5ml,B组 3 0例每天静滴谷慷太林骨肽注射液 10ml,2组均以 2 0d为 1疗程 ,共 3疗程。测量治疗前后患者的骨密度及血清Ca、P、BGP、ALP及TRAP含量。结果 :骨质疏松患者谷慷太林治疗后骨密度及血清学指标和治疗前相比变化显著 ,骨密度和血清ALP、BGP明显升高 ,血清TRAP活性显著下降 ,疼痛得到有效缓解 ;10ml组骨密度及血清学指标的变化较 5ml组明显。结论 :谷慷太林骨肽注射液可促进成骨、抑制破骨细胞的骨吸收 ,增加骨量 ,改善骨质疏松 ,且大剂量治疗效果优于小剂量。

Objective:To study the effect of injection of Gukuangtailing on bone density and serum enzyme of osteoporosis patients.Methods:Fifty-eight patients were categoried as A or B group according to unpaired principle.Twenty-eight cases in group A were dropped in vein for injecting Gukangtailing 5ml every day,30 cases in B group done for 10ml.The therapeutic period was 20 days and the therapeutic term was 3 periods,comparing bone density,the concentrations of Ca,P,BGP,ALP and TRAP in serum preoperatively and postoperatively.Result:Bone density and indexes in serum difference in osteoporosis patients preoperative and posterative were significant by the effect of injection of Gukuangtailing.Bone density,the concentrations of BGP and ALP in serum were elevated while TRAP in serum was descent.Patient's pain was lessen.The group of 10ml was better than the group of 5ml.Conclusion:Bone peptide injection Gukuagtailing can promote bone formation and depress absorption of osteoclast,increasing bone density and treating osteoporosis.The larger dose is better than the little.