苯那普利对原发性高血压左室肥厚与QT离散度的干预

The Effect of Benazapril on Left Ventricular Hypertrophy and QT Dispersion in Patients with Essential Hypertension

目的:探讨苯那普利对原发性高血压(EH)左室肥厚(LVH)与QT离散度(QTd)的干预作用。方法:对36例EH伴有LVH患者给予口服苯那普利10mg/日,1次/日(qd);服药4周时若患者BP≥160/100mmHg,则苯那普利剂量增加至20mgqd,总疗程26周。治疗前后用彩色超声多普勒检测左室相关参数,并计算出左室重量指数(LVMI);用ECG计算出QTd、校正的QTd(QTcd)。结果:(1)治疗后的LVMI、QTd和QTcd分别较治疗前显著降低,差别具有显著性(P<0.01)。(2)治疗前的QTd、QTcd分别与治疗前的LVMI呈显著正相关(r=0.79,P<0.01及r=0.77,P<0.01),治疗后的QTd和QTcd的降低程度分别与LVMI降低程度呈显著正相关(r=0.77,P<0.01及r=0.75,P<0.01)。结论:苯那普利能有效地逆转EH患者LVH,降低QTd、QTcd;QTd与QTcd可作为LVH逆转的评估指标。

To investigate the ettect ot benazapnl on left ventricular hypertrophy (LVH)and QT dispersion (QTd) of the patients with essential hypertension (EH). Methods: Thirty six patients with EH and LVH were treated with benazapril 10mg qd. If BP≥160/100 mmHg was remained after 4 weeks treatment, then the dose of benazapril was doubled. The treatment lasted for 26 weeks. LVMI was made by heart Doppler ultrasound before and after the treatment; QTd and corrected QTd (QTcd) were measured by electrocadiogram before and after the treatment. Results: (1) after treatment of 26 weeks, LVMI、QTd and QTcd were significantly less than those before treatment (all P<0.01). (2) Before treatment QTd and QTcd are positively related to LVMI respectively (r = 0.79, P< 0.01 and r = 0.77, P< 0.01); After treatment the decreased degree of QTd and QTcd are positively related to that of LVMI respectively( r = 0.79, P< 0.01及r = 0.77, P< 0.01). Conclusion : Benazapril can reverse LVH and decrease QTd、QTcd in patients with EH. QTd and QTcd are of predictive value in the assessment of effect on reversing LVH in patients with EH.