4′-溴-6-甲基-8-氰甲基黄酮的全合成

Synthesis of 4′-Bromo-6-methyl-8-cyanomethyl Flavone

探索黄酮醋酸类化合物的合成方法。通过酰基化、Fries重排、氯甲基化、氰化、缩合及 I2 /DMSO/H2 SO4 关环氧化合成 4′-溴 -6-甲基 -8-氰甲基黄酮 ,获得了满意的收率 (69.5 % )。采用新方法合成了鲜见文献报道的两个新化合物 2′-羟基 -3′-氰甲基 -5′-甲基 -4-溴查耳酮和 4′-溴 -6-甲基 -8-氰甲基黄酮 ,并对各步主要产物进行了结构表征。该方法具有反应时间短、操作简便、收率好等优点。

The synthetic methods of the intermediates of the substituted flavone 8 acetic acids were studied. The syntheses were carried out via acylating, Fries rearrangement, chloromethylating, cyanating, condensation and oxidization. By the new method, new compounds such as 2′ hydroxyl 3′ cyanomethyl 5′ methyl 4 bromo chalcone and 4′\|bromo 6 methyl 8 cyanomethyl flavone were synthesized. This method is characterized by the short reaction time, the simple operation and the good yieid.