模板结构与分子印迹效果间关系的研究

Relationship between Template Structure and Its Imprinting Efficiency

以一些分子量和体积都较小的简单化合物作为模板分子 ,合成分子印迹聚合物 .通过总结 43种化合物的分子印迹聚合物的色谱数据 ,来研究模板分子的分子量、作用位点数目、分子刚性等因素与印迹效果的关系 .根据免疫学中免疫原性的定义 ,我们提出“印迹原性”的概念 ,即 ,化合物能够产生印迹效应的性质称为印迹原性 ;具有印迹原性的化合物称为印迹原 ;并讨论了具有较强选择性的印迹原的化学基础 .所得到的结论将有助于对分子印迹聚合物的识别机理的进一步理解 ,并且对于根据模板分子性质预测MIP分子识别能力将具有一定的指导意义 .

Molecularly imprinted polymers (MIPs), were synthesized. using some simple compounds of small size as templates. This paper focuses on studying the relationship between the effect of molecular imprinting and the structural characteristics of the molecules, by summarizing the chromatographic data of 43 compounds on their corresponding MIPs. According to the definition of immunogenicity in immunology, a new term 'imprintogenicity' is proposed, which is used to describe the capability of a molecule in imprinting. The imprinting property of a molecule is termed as imprintogenicity. Accordingly, a molecule which owns imprintogenicity is called imprintogen. An imprintogen with high imprintogenicity will produce molecularly imprinted polymer with high binding constant and high selectivity to the template or imprintogen. The chemical basis of being an imprintogen with high imprintogenicity is studied. The conclusions drawn in this paper will be helpful to understand the mechanism of molecular recognition of MEP. Furthermore, it will be of instructive significance to predict the selectivity of MIPs according to the properties of templates.